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If I Had a Hammer: Purdue’s Anvil Supercomputer Will See Use All Over the Land

The project director of the new accelerated system at Purdue shares the story of her path to leadership in high performance computing.
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Purdue Anvil AI supercomputer

Carol Song is opening a door for researchers to advance science on Anvil, Purdue University’s new AI-ready supercomputer, an opportunity she couldn’t have imagined as a teenager in China.

“I grew up in a tumultuous time when, unless you had unusual circumstances, the only option for high school grads was to work alongside farmers or factory workers, then suddenly I was told I could go to college,” said Song, now the project director of Anvil.

And not just any college. Her scores on a national entrance exam opened the door to Tsinghua University, home to China’s most prestigious engineering school.

Along the way, someone told her computers would be big, so she signed up for computer science before she had ever seen a computer. She learned soon enough.

“We were building hardware from the ground up, designing microinstructions and logic circuits, so I got to understand computers from the inside out,” she said.

Easing Access to Supercomputers

Skip forward a few years to grad school at the University of Illinois when another big door opened.

While working in distributed systems, she was hired as one of the first programmers at the National Center for Supercomputing Applications,  one of the first sites in a U.S. program funding supercomputers that researchers shared.

To make the systems more accessible, she helped develop alternatives to the crude editing tools of the day that displayed one line of a program at a time. And she helped pioneering researchers like Michael Norman create visualizations of their work.

GPUs Add AI to HPC

In 2005, she joined Purdue, where she has helped manage nearly three dozen research projects representing more than $60 million in grants as a senior research scientist in the university’s supercomputing center.

“All that helped when we started defining Anvil. I see researchers’ pain points when they are getting on a new system,” said Song.

Anvil links 1,000 Dell EMC PowerEdge C6525 server nodes with 2,000 of the latest AMD x86 CPUs and 64 NVIDIA A100 Tensor Core GPUs on a NVIDIA Quantum InfiniBand network to handle traditional HPC and new AI workloads.

The system, built by Dell Technologies, will deliver 5.3 petaflops and half a million GPU cycles per year to tens of thousands of researchers across the U.S. working on the National Science Foundation’s XSEDE network.

Anvil Forges Desktop, Cloud Links

To harness that power, Anvil supports interactive user interfaces as well as the batch jobs that are traditional in high performance computing.

“Researchers can use their favorite tools like Jupyter notebooks and remote desktop interfaces so the cluster can look just like in their daily work environment,” she said.

Anvil will also support links to Microsoft Azure, so researchers can access its large datasets and commercial cloud-computing muscle. “It’s an innovative part of this system that will let researchers experiment with creating workflows that span research and commercial environments,” Song said.

Fighting COVID, Exploring AI

More than 30 research teams have already signed up to be early users of Anvil.

One team will apply deep learning to medical images to improve diagnosis of respiratory diseases including COVID-19. Another will build causal and logical check points into neural networks to explore why deep learning delivers excellent results.

“We’ll support a lot of GPU-specific tools like NGC containers for accelerated applications, and as with every new system, users can ask for additional toolkits and libraries they want,” she said.

The Anvil team aims to invite industry collaborations to test new ideas using up to 10 percent of the system’s capacity. “It’s a discretionary use we want to apply strategically to enable projects that wouldn’t happen without such resources,” she said.

Opening Doors for Science and Inclusion

Early users are working on Anvil today and the system will be available for all users in about a month.

Anvil’s opening day has a special significance for Song, one of the few women to act as a lead manager for a national supercomputer site.

Carol Song. project director, Purdue Anvil supercomputer
Carol Song and Purdue’s Anvil supercomputer

“I’ve been fortunate to be in environments where I’ve always been encouraged to do my best and given opportunities,” she said.

“Around the industry and the research computing community there still aren’t a lot of women in leadership roles, so it’s an ongoing effort and there’s a lot of room to do better, but I’m also very enthusiastic about mentoring women to help them get into this field,” she added.

Purdue’s research computing group shares Song’s enthusiasm about getting women into supercomputing. It’s home to one of the first chapters of the international Women in High-Performance Computing organization.

Purdue’s Women in HPC chapter sent an all-female team to a student cluster competition at SC18. It also hosts outside speakers, provides travel support to attend conferences and connects students and early career professionals to experienced mentors like Song.

Pictured at top: Carol Song, Anvil’s principal investigator (PI) and project director along with Anvil co-PIs (from left) Rajesh Kalyanam, Xiao Zhu and Preston Smith. 

How Open Science Can Help Researchers Prepare for the Next Pandemic

NVIDIA is collaborating with organizations including Google DeepMind and the European Molecular Biology Laboratory’s European Bioinformatics Institute to release an open dataset of viral protein structures — giving scientists a head start against diseases.
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When COVID-19 emerged, scientists had a crucial advantage: Decades of prior research on coronaviruses meant they understood the virus’ key proteins well enough to design vaccines in record time. The next pandemic may not offer the same head start. 

To help improve the odds, NVIDIA has joined a coalition of global research organizations, including Google DeepMind and the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), to release predicted 3D structures for the protein complexes of more than 2,800 viruses — openly available to any scientist, anywhere, through the AlphaFold Database.

The structures in the newly released dataset were inferred using AlphaFold2 — Google DeepMind’s AI model for predicting how proteins fold into 3D shapes — with optimization from NVIDIA BioNeMo Inference Runtime. This allowed the team to scale inference to thousands of viral proteomes, predicting the complexes, or groups of interacting proteins, encoded within each virus. 

“Our ambition with the AlphaFold Database has always been to democratize access to foundational biology at scale,” said Risha Patel, life sciences partnerships manager at Google DeepMind. “This collaboration to bring thousands of viral complexes into the database will equip scientists around the world with insights they need to help prepare for future outbreaks.”

NVIDIA is also openly releasing the BioNeMo Structure Prediction Pipeline, the GPU-accelerated workflow used to generate the dataset, so researchers can go from protein sequence to predicted 3D structure for their own targets.

Preparation for the next pandemic must begin now. An analysis by the Center for Global Development estimates a roughly 50% chance of the world facing a pandemic as severe as COVID-19 by 2050.

“When the next pandemic happens, there may be something that comes out of the blue, and we’ll be lacking the knowledge we had for COVID,” said Joe Grove, professor of molecular virology at the Medical Research Council-University of Glasgow Centre for Virus Research and a collaborator on the project. “What we’re trying to do is stockpile some of that knowledge ahead of time.”

About 30% of the protein interactions being added to the database are completely new to science, showing interaction shapes that have never been documented in the Protein Data Bank, the main repository of experimentally determined protein structures. This translates to new insights for the biological community to explore and harness to generate new knowledge.

“This database is an engine for hypothesis generation,” said Chris Dallago, applied research science team lead in digital biology at NVIDIA. “We’re enabling biologists and the AI community to investigate protein interactions, not just as single molecules but as complexes, so the whole field can move forward.”

Predicting Complex Protein Structures

Most proteins don’t work alone — they come together in complexes of multiple molecules to perform sophisticated functions. Those structures are often what a vaccine or drug must target to disrupt viral function. 

Understanding the 3D structure of the COVID-19 virus’ spike protein, for example, proved foundational to vaccine design. For thousands of other viruses, no such structural knowledge exists today. This dataset begins to fill that gap.

Traditional methods for determining protein structures — crystallizing proteins and shooting X-rays at them — can take years and cost thousands of dollars per structure. AlphaFold2, which was optimized with NVIDIA BioNeMo to efficiently run on NVIDIA GPUs, predicts a structure in minutes and can be run in bulk. Scientists can then verify high-confidence predictions through experimental methods. 

For this project, the team systematically worked through the protein structures of viral families known to infect humans, from common-cold viruses to emerging threats like Mpox. 

A Global Collaboration With Global Access

The collaboration spans the Coalition for Epidemic Preparedness Innovations, EMBL-EBI, Google DeepMind, NVIDIA, Seoul National University, Sungkyunkwan University, the Swiss Institute of Bioinformatics and the University of Glasgow. 

The dataset release — coinciding with a United Nations General Assembly meeting convened by the World Economic Forum on pandemic prevention, preparedness and response taking place this week in New York City — contributes to the AlphaFold Database, which now holds more than 260 million protein and protein complex predictions covering nearly every cataloged protein known to science.

“Making this data open is critical for understanding viral diagnostics and developing treatments and vaccines,” said Jo McEntyre, interim director of EMBL-EBI. “The dataset also covers lesser-studied viruses and lowers the barriers for scientists in low-resource settings who are confronting outbreaks firsthand.”

Predictions in the open dataset are labeled by confidence. The structures show what viral complexes may look like and how individual proteins might interact within a viral proteome. 

Overall, the new data represents a major contribution to the information available for scientists across digital biology and disease research.

“When I did my Ph.D., there were no structures for any of the proteins we were investigating. It was like working in the dark — we had to guess what was going on,” said Grove. “This dataset is a powerful tool for all the researchers doing their Ph.D.s now, giving them high-quality structural data that’s going to accelerate fundamental science.”

Explore the viral protein complex dataset on the AlphaFold Database Pandemic Preparedness Portal, predict structures for protein targets with the BioNeMo Structure Prediction Pipeline, and learn more about NVIDIA BioNeMo.

At AI Day Singapore, NVIDIA and Partners Showcase AI Advancements Across Southeast Asia

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NVIDIA AI Day Singapore, which takes place Sept. 22-23 at the Raffles City Convention Centre, is offering attendees opportunities to explore the hands-on training, expert-led sessions and advanced tools to accelerate their work in AI and high-performance computing.

At the event, NVIDIA and its partners are showcasing breakthrough AI advancements across the Southeast Asia region at large.

Read more about these announcements below.


NVIDIA Accelerates Public Sector AI from Pilot to Production in Southeast Asia 🔗

AI is becoming a matter of national strategy, with governments looking to move from pilots to production and deliver impact at scale, while building trusted AI capabilities that reflect local languages, cultures, priorities and economic needs. 

NVIDIA is working to enable all nations to be AI nations — providing the technology, infrastructure, ecosystem and expertise needed to make this possible.

To accelerate this transition across Southeast Asia, NVIDIA is helping nations move AI from experimentation to production-scale deployment through open models, developer tools and a broad partner ecosystem. 

Together, NVIDIA and its partners are focusing on four key areas: 

  • Enhancing government operations and service delivery.
  • Developing accessible AI-powered citizen services, and empowering local businesses.
  • Strengthening critical infrastructure and public safety.
  • Supporting startups, developers and researchers to strengthen national AI capabilities and innovation in each country. 

Singapore’s HTX (Home Team Science and Technology Agency) is embarking on research using the NVIDIA Nemotron 3 Super and Nemotron 3 Nano Omni models to advance AI for public safety. Nemotron Super has the potential to support the agency’s complex reasoning and agentic workflows, while Omni’s unified vision, audio and language capabilities could help HTX develop multimodal applications grounded in real-world operational data. Together, the models could strengthen HTX’s ability to deploy secure, locally controlled AI across Singapore’s Home Team.

NCS is advancing agentic AI adoption across enterprises and the public sector, using Nemotron models and the NVIDIA Blueprint for video search and summarization (VSS), while advancing physical AI for practical humanoid robotics applications, to address security, responsiveness and data governance requirements. ST Engineering is using NVIDIA NeMo tools and NVIDIA cuOpt software to develop its AI Studio platform and deploy agentic AI solutions across its businesses such as Marine MRO.

Beyond Singapore, similar work is already underway across the region. Malaysia’s YTL AI Labs is fine-tuning Nemotron models for enterprise and citizen services, while Viettel AI is doing the same for Vietnamese-language applications. 

In Thailand, the Big Data Institute and iApp Technology, as members of the ThaiLLM Collaboration, are exploring Nemotron as a foundation model. With an initial focus on legal applications, iApp Technology is adapting Nemotron 3 Nano by fine-tuning OpenThai 2.0 Legal with Thai-language legal data using the NVIDIA NeMo framework. 

The model is released as open source for the Thai developer community and serves as the engine for Thanoy, the company’s legal-assistant chatbot, which already serves approximately 43,000 users. 

In Brunei, Antrique built an AI innovation platform to help boost productivity across the nation’s food sector.  

Across the region, NVIDIA Cosmos open world models and the NVIDIA VSS Blueprint are advancing smart city solution development. Malaysia’s ITMAX uses Cosmos with VSS to improve city traffic operations, while Thailand’s AS-TECH applies the same stack to improve passenger flow in airports. 

Learn more about NVIDIA Nemotron and Cosmos models and read about NVIDIA’s participation in the Open Secure AI Alliance.


Southeast Asia Technology Leaders Build With NVIDIA Nemotron Open Models for Region-Specialized AI 🔗

Leading enterprises, technology providers and research organizations across Southeast Asia are building region-specialized AI models and applications with NVIDIA Nemotron open models, datasets and libraries — accelerating the development of AI tailored to the region’s languages, industries and communities.

NVIDIA Nemotron provides a foundation for regional AI ecosystems, letting organizations customize, control and own models that address their specific requirements. Nemotron also offers persona datasets that provide locally relevant synthetic data reflecting the region’s populations, languages and workforces.

Across the region, partners are building applications spanning public services, services and healthcare.

NVIDIA Nemotron Adoption Expands in Singapore

Enterprises in Singapore are adopting NVIDIA Nemotron for various use cases. AI Singapore is expanding its SEA-LION model family to include the NVIDIA Nemotron open models and NVIDIA NeMo tools. SEA-LION is an open model family designed for Southeast Asian languages and cultures.

Hummingbird Bioscience, together with LynxKite, is building an explainable Toxicity Knowledge Graph powered by Nemotron 3.5 Lightning and NeMo Retriever with in silico simulations. The collaboration aims to integrate complex public and proprietary data across diverse third-party file formats, creating a comprehensive, unified foundation for robust analysis and reasoning that helps de-risk and accelerate drug discovery and development.

Across Asia Pacific, NVIDIA Nemotron Enables Region-Specific AI

Bitdeer AI co-hosted the Open Models AI Codefest with NVIDIA, providing the GPU cloud infrastructure that enabled developers across the region to use NVIDIA Nemotron open models, datasets and training recipes to accelerate localized applications across critical sectors, including healthcare. 

In Vietnam, Viettel AI has been extensively fine-tuning Nemotron 3 Super for the Vietnamese language and agentic applications. The model achieved the highest ranking on both the VMLU benchmark and the company’s in-house product benchmark, and it’s set to be adopted in Legal AI — an agent harness that will serve both internal Viettel Group employees and external customers.

Also in Vietnam, FPT Smart Cloud codeveloped Nemotron-Personas-Vietnam, an open dataset grounded in Vietnamese demographic and cultural data, and is enabling local developers to post-train and evaluate localized AI models.

Get started building with NVIDIA Nemotron using skills and playbooks that help partners customize Nemotron open models for their languages and domains.

Stay up to date on agentic AI, NVIDIA Nemotron and more by subscribing to NVIDIA news, joining the community and following NVIDIA AI on LinkedIn, Instagram, X and Facebook.  

Explore self-paced video tutorials and livestreams.


Sea the First in ASEAN Region to Adopt NVIDIA Vera Rubin, Scaling AI to Better Serve Communities Across Southeast Asia 🔗

Sea Limited, a global technology company founded in Singapore, is the first enterprise in the ASEAN region to adopt the NVIDIA Vera Rubin platform, further strengthening the company’s AI capabilities to better serve and create meaningful economic opportunities for millions of consumers and small businesses across Southeast Asia. 

Serving hundreds of millions of users through its Garena, Monee and Shopee platforms, Sea has already deployed AI across its businesses to make its services more useful and accessible. Now, with NVIDIA Vera Rubin, Sea will build on these efforts, developing and deploying AI models and intelligent agents at greater scale to serve the evolving needs of its communities. 

On Shopee, AI is already helping sellers reduce the time and effort required to create informative product listings, improve product discovery and deepen customer engagement, while enabling better-informed business decisions. These capabilities enable small- and medium-sized enterprises in Southeast Asia, many of which operate with limited resources, to scale their businesses using enterprise-grade AI technologies previously accessible only to large corporations.

Across Monee, the digital financial services division of Sea, AI is being applied in areas such as fraud detection and credit risk assessment, supporting Monee’s ability to deliver simple, accessible and inclusive digital financial services. For small businesses and consumers underserved by traditional financial services, these capabilities can expansively broaden access to financial tools.       

At Garena, Sea’s digital entertainment and video game arm, AI is used to enhance gaming experiences supporting the company’s efforts to create engaging, inclusive and safe online spaces that bring players together.

NVIDIA Vera Rubin will provide the advanced computing infrastructure to build on this foundation — enabling Sea to accelerate innovation, scale AI applications more broadly and deepen its impact for the communities it serves.

Learn more about NVIDIA Vera Rubin.

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From Enablement to Execution, Egypt’s AI Ecosystem Reaches Production Scale

AI factories are also coming online across South Africa, Morocco and Nigeria, enabling Africa’s developers and enterprises to reach production-scale compute onshore.
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Today, Egypt’s AI builders gathered in the Grand Egyptian Museum for a reception that highlighted the nation’s rapidly growing AI ecosystem — spanning AI natives, developers, researchers, startups and enterprises — building applications across industries.

The event included a keynote from Paolo Guglielmini, vice president of EMEA at NVIDIA. Ahmed Mostafa, regional AI adoption lead for the Middle East and Africa at NVIDIA, delivered a session on “Why Accelerating Every Layer Matters,” exploring NVIDIA’s full-stack approach to AI development and deployment.

The event also featured a panel moderated by Basil Fateen, head of startups for the Middle East and Africa at NVIDIA, with participation from startups across smart spaces, healthcare, cybersecurity and robotics.

In Egypt, the NVIDIA Deep Learning Institute learner base grew more than tenfold in a single year. In June, the National Telecommunications Regulatory Authority of Egypt licensed Hassan Allam Data Centers to build and operate data centers in the country. Under that license, Hassan Allam Utilities and investment firm A15 agreed to develop a new data center, an estimated $400 million investment.

In addition, NVIDIA and A15 in July hosted an event connecting Egypt’s leading founders with NVIDIA’s global ecosystem. This has been complemented by recent startup and investor events in Egypt, including engagements with A15 and Plug and Play at the Creativa Innovation Hub at Sultan Hussein Kamel Palace, an affiliate of the Ministry of Communications and Information Technology.

Spanning a range of industries, members of the NVIDIA Inception program in Egypt include:

  • Aidera: A unified enterprise intelligence system that connects data, systems, workflows and operational touch points turning enterprise-wide signals into informed decisions, intelligent automation, coordinated execution and measurable impact.
  • Intella: Developing Arabic speech intelligence for applications across financial services, telecommunications and more.
  • Marses Robotics: Developing autonomous robotics and industrial automation technologies.
  • Proteinea: Combining AI protein design with lab experiments to develop differentiated medicines.
  • Stakpak: Developing an open source autonomous developer-operations AI agent.
  • Paymob and Thndr: Building better financial services through technology and AI. 

The NVIDIA VC Alliance has also expanded its presence in Egypt, with A15 and M Empire joining the program, connecting more local investors with NVIDIA’s global startup ecosystem. This momentum has been complemented by startup and investor events, including collaborations with RiseUp and Plug and Play, as well as Flat6Labs, a regional entrepreneurship platform supporting startups and innovation across emerging markets, and Algebra Ventures, a Cairo-based venture capital firm backing technology startups.

AI Growth Across Africa

The Egypt ecosystem event showed just a piece of Africa’s larger, growing AI ecosystem. 

For most of the past decade, conversations about Africa’s AI ecosystem revolved around “potential.” They centered on what the technology might do for the continent, rather than what the continent could build with it.

Africa is home to roughly 18% of the world’s population but less than 1% of the world’s data center capacity. This means African developers have often relied on cloud-based compute hosted outside the continent for large-scale AI training.

This is rapidly changing. Within a year, four AI factories have been announced or brought online across Africa, with another 656 megawatts of new capacity in the pipeline. These AI factories will provide African developers and enterprises with the accelerated computing infrastructure needed to train, fine-tune and deploy AI models closer to where data is created.

Cassava Technologies, Africa’s first NVIDIA Cloud Partner, is expanding access to NVIDIA accelerated computing through its AI factory in South Africa and planned deployments across Egypt, Kenya, Nigeria and Morocco — an investment that could reach $720 million. In Egypt, Cassava and Vodafone Egypt recently announced an AI factory initiative to provide businesses and government organizations with locally hosted AI infrastructure through GPU-as-a-service, supporting the development and deployment of AI applications while keeping data in-country. 

Building on Cassava’s first AI factory in South Africa, the rollout aims to expand access to local accelerated computing, helping developers, enterprises and researchers train, customize and deploy AI models closer to where their data is created.

Similarly, Stratos Lab, a South African AI neocloud provider, is partnering with ECOBLOX and Digital Parks Africa to launch an AI cloud powered by more than 50 NVIDIA HGX B300 systems — delivering over 7 exaflops of performance. The deployment gives African enterprises and developers access to high-performance GPU compute locally, enabling model training, inference and agentic AI workloads with lower latency and at reduced costs.

And at GITEX Africa in Marrakech in April, Nexus Core Systems announced a collaboration with Morocco’s Ministry of Digital Transition, its Ministry of Investment and the investment agency AMDIE to build the Nexus AI factory outside Casablanca: a $1.2 billion initial investment with 500 megawatts planned, NVIDIA Blackwell accelerated computing and renewable power from TAQA Morocco.

The Demand Was Already There

Infrastructure of this kind is not based on mere potential — it’s based on confidence that local developers and enterprises are ready to put the infrastructure to productive use.

In 2024, NVIDIA set a target of training 100,000 developers across Africa through the NVIDIA Deep Learning Institute within three years. To date, NVIDIA’s trained over 85,000 developers in Africa, and the continent is among NVIDIA’s fastest-growing developer regions — Nigeria is now the institute’s second-largest market globally.

InstaDeep joined NVIDIA Inception in 2017 as a small team in Tunis using its first NVIDIA DGX system. Since then, it’s developed drug discovery, protein design and logistics optimization applications, and was acquired by BioNTech for about $680 million.

Africa accounts for roughly a third of the world’s languages, often invisible to frontier models. To help advance African language models, language model lab Lelapa AI built InkubaLM and the Vulavula speech service for South African languages including isiZulu and Sesotho.

MeetKai, for example, an NVIDIA Inception member, is expanding its work in Egypt with Smart Africa, building its AI stack on NVIDIA technology as part of its plans for the market. The company is among a growing group of AI innovators using NVIDIA technology to build and scale across Africa.

And there’s still much room to grow. McKinsey puts African data center demand at roughly 0.4 gigawatts today, and estimates it will rise to between 1.5 and 2.2 gigawatts by 2030, which requires between $10 to $20 billion in construction.

Learn more about the NVIDIA Developer Program, NVIDIA Inception and NVIDIA Deep Learning Institute.  

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