More knowledge means more informed predictions. That’s the principle San Diego-based startup Entos is applying to revolutionize drug design with an AI-powered approach that enables a thousandfold acceleration in molecular properties prediction.
Drug discovery is a notoriously time-consuming and data-intensive process, but Entos’ OrbNet architecture changes that. It requires 30x less data to train a model for molecular drug discovery with quantum accuracy and 100x fewer experiments to find promising drug compounds — cutting through the waiting time and complexities associated with traditional therapeutic drug discovery methods.
The company, a member of the NVIDIA Inception program for startups revolutionizing industries with advancements in AI, data science and high performance computing, is advancing its work with NVIDIA Clara Discovery — a collection of state-of-the-art frameworks, applications and pretrained models built to unlock insights about how billions of potential drug molecules interact inside our bodies.
“Our physics-based approach means we include more qualities about the underlying quantum mechanics into the machine learning model,” said Tom Miller, CEO of Entos. “This enables us to make better predictions, even while using less data.”
Entos is focusing on identifying drug molecules that could deactivate proteins linked to certain forms of cancer. By including quantum mechanics calculations into its machine learning workflow, the startup can more quickly narrow the pool of potential compounds that bind with these target proteins.
Bringing AI Into the Drug Discovery Process
Machine learning is transforming the way scientists approach everything from climate science to drug discovery. Now the combination of AI and machine learning is leading to a new way of doing science, creating a hybrid of deep learning and physics-based simulation to transform the way drugs are discovered.
Drug discovery is a data-intensive process where researchers perform computationally dense calculations to simulate how molecules and proteins interact to identify the right therapeutics. Traditionally, these forms of quantum calculations are extremely expensive to perform and take weeks or months to complete.
These computational experiments benefit from the incorporation of AI and accelerated computing by allowing researchers to simulate the interaction of a drug with a protein at quantum accuracy. The simulations are far too computationally expensive to perform using traditional quantum mechanical calculations.
Entos optimizes its OrbNet drug discovery software on NVIDIA DGX A100 Tensor Core GPUs. The OrbNet AI model — developed jointly at Caltech by Entos CEO Tom Miller and Anima Anandkumar, director of machine learning research at NVIDIA — enables robotic synthesis and high-throughput experimentation to speed up therapeutic design.
“OrbNet uses a graph neural network built on domain-specific features that account for interactions between atoms. Further, we account for symmetries such as three-dimensional rotations,” said Anandkumar. “These design considerations make it possible to train OrbNet only on small molecules — those with less than 40 atoms — and directly apply the model on large protein molecules with a high degree of accuracy.”
By collaborating with NVIDIA experts, Miller’s team of scientists is able to perform high-throughput experimentation and “open new doors to what we can go after,” he said.
Unlocking the Potential of Covalent Bonds
Recent developments in machine learning are transforming the size and scale of chemical databases that researchers can trawl for promising drug compounds. AI models also allow scientists to study the innumerable chemical reactions of enzymes within the body in a new way.
Together, these advancements are enabling the study of entirely new classes of drugs that researchers were unable to investigate with previous methods.
One promising technique involves the creation of drug molecules that form covalent bonds with the target protein. If therapeutics can form these bonds with only the target protein, patients could be prescribed smaller doses and experience fewer side effects. Entos researchers plan to apply this method to disease areas including cancer, diabetes and cystic fibrosis.
Entos has forged partnerships with leaders in the pharmaceuticals, materials and chemical industries and raised $53 million in July to support its efforts to create meaningful therapies with high accuracy. The company credits active collaborations with the NVIDIA healthcare team as an asset in getting connected to technical resources and assistance in optimizing its applications on NVIDIA hardware architecture.
NVIDIA’s Gamescom announcements are revealing what’s next for GeForce NOW, with new ways to play, more supported devices and platforms, and even more big PC games headed to the cloud.
New NVIDIA DLSS 4.5 technology controls give members more ways to fine-tune gameplay, while expanded support for new Steam devices, GOG single sign-on, Firefox browser support and more Amazon Fire TV devices continue broadening where and how GeForce RTX-powered PC gaming can be enjoyed.
Gamescom is also bringing a blockbuster lineup of PC games to GeForce NOW. CONTROL Resonant, Gears of War: E-Day, Onimusha: Way of the Sword, The Blood of Dawnwalker and STAR WARS Zero Company are all coming to the cloud at launch.
For a limited time, members can also get CONTROL Resonant with the purchase of a 12-month GeForce NOW Ultimate membership.
The Gamescom extras don’t stop there. To celebrate, GeForce NOW is giving away more than 40 prizes in our Community Giveaway — including gaming hardware and GeForce NOW Ultimate memberships.
There’s even more fun to come. Check out the list of 13 games joining the GeForce NOW library this week.
Next-Level Cloud Gaming
More ways to choose how to play.
This fall, GeForce NOW is introducing new NVIDIA DLSS 4.5 controls in the cloud, giving Ultimate members more choice over how supported games look and perform, even without the latest hardware. Powered by NVIDIA RTX graphics, each control offers something different: DLSS Super Resolution sharpens image quality, while Dynamic Frame Generation delivers lower latency and stutter for smoother streaming, and Ray Reconstruction enhances ray-traced visuals. Together, these technologies make it easier to tune supported games for image quality, responsiveness or a preferred balance between the two.
Stay tuned to GFN Thursdays for details about best practices for enabling DLSS 4.5 overrides and how Dynamic Frame Generation can help Ultimate members enable more graphic settings while still getting smooth streaming.
Stream full steam ahead with the Steam ecosystem.
GeForce NOW is also adding community-requested support for Steam Machine with Steam Controller later this fall, and later for Windows and macOS, delivering more ways to play and making it even easier for longtime Steam players to jump into the cloud using familiar hardware. The additions build on existing Steam Deck support and expand compatibility across the Steam ecosystem.
Get your GOG on with one click into the library.
Launching GOG games just got even easier. With GOG single sign-on now available on GeForce NOW, members can securely link their account once, automatically sync supported games and launch them without having to sign in to GOG again — all with a single click.
With fewer steps between opening the app, skipping any downloads and jumping into gameplay, it’s another way GeForce NOW continues streamlining access to PC gaming libraries, making it easier to play the GOG library of games on TV platforms since gamers are automatically logged into their GOG accounts.
Find popular titles, like Cyberpunk 2077 and The Witcher 3: The Wild Hunt, in the app in the dedicated GOG row. Or search and filter for GOG games, then jump into supported titles from almost anywhere — all streamed from the cloud. Check back on GFN Thursdays for the latest games joining the GeForce NOW library, including newly supported games streaming from GOG.
Outfox nearly any device with GeForce RTX gaming.
Plus, GeForce NOW is now officially supported on Firefox, expanding browser access across all major Windows browsers. Members can jump into supported PC games directly from Firefox without downloading a dedicated app. Ultimate members can enjoy GeForce RTX-powered gaming at up to 1440p and 120 frames per second.
Simply download the latest version of Firefox and visit play.geforcenow.com to get started. The cloud handles downloads, installs and updates, keeping local storage free while games stay ready to play in the cloud.
Bring the fire to living rooms with GeForce NOW.
GeForce NOW is expanding support to additional Amazon Fire TV devices. GeForce NOW first launched on Fire TV devices earlier this year, and will soon expand to the Fire TV Stick 4K Select, a 4K streaming stick that’s ready to game right out of the box. Streaming from the cloud means supported PC games are ready to play using a compatible controller, making it easy to enjoy GeForce NOW on the biggest screen in the house with even more options to play from the comfort of the couch.
And that’s not all the awesomeness from Amazon. Later this year, Fire TV users will be able to purchase GeForce NOW memberships directly through Amazon, creating a more seamless path from device setup to gameplay.
These new features will arrive alongside some of the biggest games coming to the cloud throughout the year.
Get Ready for Launch
Five newly announced and highly anticipated games are coming to GeForce NOW at launch: CONTROL Resonant, Gears of War: E-Day, Onimusha: Way of the Sword, The Blood of Dawnwalker and STAR WARS Zero Company.
Better yet, members can lock in one of them early: For a limited time, purchase a 12-month GeForce NOW Ultimate membership and receive CONTROL Resonant at launch at no additional cost, and be first to experience Faden’s next chapter. The offer is available Tuesday, Aug. 25, through Sunday, Sept. 27.
Ultimate members can stream the full lineup with GeForce RTX 5080-class performance in the cloud, including NVIDIA DLSS 4, ray tracing, NVIDIA Reflex and Cinematic Quality Streaming technologies, with up to 5K high dynamic range on supported devices.
Whether diving into new worlds or returning to iconic franchises, GeForce NOW lets members skip expensive hardware upgrades, massive installs and storage management so they can jump straight into the action the moment each game launches. Here’s a closer look at what’s coming:
Contain the chaos.
Explore a warped Manhattan on the brink of paranatural annihilation in Remedy’s CONTROL Resonant. Harness Dylan Faden’s extraordinary powers to battle the Hiss, the Mold and other reality-bending threats while searching for his sister, Federal Bureau of CONTROL Director Jesse Faden.
Emergence begins.
Experience the horror and brutality of Emergence Day in the Coalition’s Gears of War: E-Day. Fourteen years before the original Gears of War, join Marcus Fenix and Dominic Santiago in a gripping origin-story campaign as the Locust Horde first erupt from below, igniting a desperate fight for survival. Rally squads and fight on in multiplayer with a reimagination of Gears’ iconic PvE mode, Horde Siege, or go head to head with a refined versus PvP.
Pick up the Oni Gauntlet.
Fight across a twisted vision of Edo-period Kyoto in Capcom’s Onimusha: Way of the Sword. Wield the mystical Oni Gauntlet, master intense swordplay and battle relentless demonic Genma beneath mysterious clouds of Malice.
Walk the line between day and night.
Step into 14th-century Europe in Bandai Namco’s The Blood of Dawnwalker, where war, plague and rising vampire powers have reshaped history. Play as Coen, a young Dawnwalker torn between humanity and cursed strength, and shape his path while fighting to save his family.
Command the galaxy’s finest.
Lead an elite squad behind enemy lines in STAR WARS Zero Company, a single-player turn-based game set during the twilight of the Clone Wars. Command former Republic officer Hawks and Zero Company through tactical battles and high-stakes missions where strategy, squad composition and player choices shape the fate of the galaxy.
More Ways to Win
Gaming gear and Ultimate memberships are up for grabs.
GeForce NOW is marking Gamescom with a community giveaway featuring more than 40 prizes. Gamers will have a chance to score a MacBook Neo, Steam Deck or Chromebook — each paired with a one-year GeForce NOW Ultimate membership — along with Amazon Fire TV Sticks and GeForce NOW Ultimate memberships ranging from one month to one year.
Head over to the GeForce NOW community on Reddit for all the giveaway details and how to enter.
The Hunt Is On
Squad up and fight for survival in Aliens: Fireteam Elite 2, streaming on GeForce NOW this week at launch. Assemble a four-player fireteam of Colonial Marines and battle through swarms of Xenomorphs, deadly new threats and increasingly desperate encounters. With deeper squad mechanics, new and improved classes, smarter enemies and expanded customization, every mission puts teamwork — and nerves — to the test.
Members can also look for the following games joining the cloud this week:
Aliens: Fireteam Elite 2 (New release on Steam, Aug. 25)
Resonance: A Plague Tale Legacy (New release on Steam and Xbox, Aug. 27, available on Game Pass)
STAR WARS Zero Company (New release on EA app and Steam, Aug. 27)
Call of Duty: Modern Warfare 4 – Open Beta Weekend (Battle.net, Steam and Xbox available from Aug. 28 10am PDT to Sep. 1 at 10am PDT. For more information please visit the Call of Duty website).
Dates listed above reflect when games are released on their respective stores. GeForce NOW availability may vary, as games are onboarded after release and added throughout the week. Keep an eye on GeForce NOW channels and GFN Thursdays for availability updates on announced titles.
To experience GeForce NOW, gamers can start with a GeForce NOW day pass and try premium cloud gaming before committing to a membership. Better yet, the cost of a day pass can be applied toward a first membership purchase, making it even easier to level up when ready.
Check back every GFN Thursday for new games, new features and even more ways to play on GeForce NOW. Which Gamescom announcement has you most excited? Let us know on X or in the comments below.
The future of PC gaming is on display with GeForce NOW. ☁️⚡
🖥️DLSS 4.5 controls 📱Expanded device support ✨ Upcoming AAA games 🎮 More ways to play 🎁 Community giveaway 🦊 Firefox browser support … and more! #gamescom
NVIDIA is bringing the next wave of RTX gaming to the Gamescom conference running this week in Cologne, Germany, with support for new games, anti-cheat technologies and increased visual quality.
Electronic Arts, Embark and Ubisoft are among the latest game publishers and developers bringing their blockbuster titles to NVIDIA RTX Spark ahead of its launch this fall. They join the publishers that announced RTX Spark support at COMPUTEX in May, including KRAFTON, NetEase, Riot Games and XBOX.
NVIDIA is working closely with game developers and ecosystem partners to ensure today’s top PC games — including EA’s EA SPORTSF1 25 and Apex Legends, Ubisoft’s Anno 117: Pax Romana and Embark Studios’ ARC Raiders and THE FINALS — run seamlessly on RTX Spark devices.
“We’re excited to bring Anno 117: Pax Romana to a new generation of RTX-powered PCs,” said Stéphane Jankowski, Ubisoft executive producer of Anno 117 : Pax Romana. “Our teams build the game to be seen wide: full districts, long sightlines, thousands of details at once. Seeing RTX Spark hold that level of fidelity from a single chip is genuinely impressive.”
RTX Spark reinvents personal computing, bringing personal AI agents, advanced content creation and high-performance gaming together in a platform engineered from the ground up for the next wave of Windows PCs. For gamers, RTX Spark combines Windows devices with NVIDIA RTX technologies, including DLSS and Reflex.
Bringing Anti-Cheat to RTX Spark
Supporting modern PC gaming goes beyond running the game itself. Many of today’s biggest online games rely on sophisticated anti-cheat technologies, to enable fair play across the multiple platforms these games run on.
NVIDIA has been working with EA to bring native EA Javelin Anticheat support to RTX Spark, including for EA’s biggest multiplayer games, such as EA SPORTS F1 25. RTX Spark launches this fall.
RTX Delivers Next-Generation Gaming
RTX Spark is just one part of NVIDIA’s lineup of gaming announcements at Gamescom, including:
DLSS 4.5 Ray Reconstruction is available now, featuring NVIDIA’s latest second-generation transformer model to deliver even higher image quality in ray- and path-traced content. It replaces traditional denoisers with an NVIDIA supercomputer-trained AI network to reconstruct higher-quality pixels in the parts of a ray-traced frame where rays were not sampled.
Path tracing comes to CONTROL Resonant and 007 First Light to deliver new levels of visual fidelity.
NVIDIA ACE technologies are coming to Aniimo in early 2027, letting players naturally interact with their creatures.
Gears of War: E-Day includes RTX Mega Geometry integration, advancing image quality on GeForce RTX GPUs, alongside ray tracing and DLSS 4.5.
RTX Remix keeps remastering PC classics, with a major Painkiller RTX mod update available now and The Elder Scrolls III: Morrowind RTX coming soon.
GeForce NOW gives members more ways to play with new DLSS 4.5 controls, expanded support for Steam Machine and other devices and platforms, plus blockbuster PC games including CONTROL Resonant, Gears of War: E-Day and more coming to the cloud at launch.
GeForce NOW welcomes Firefox support to the cloud, opening up another way to jump into high-performance PC gaming straight from the browser, starting today. Whether on a school laptop or everyday PC, it’s now even easier to play supported PC games without downloading a dedicated app.
Plus, discover 12 new games streaming from the GeForce NOW library this week, led by Gallipoli.
No Downloads. Just Firefox.
This cloud is on fire with new ways to play on Firefox.
GeForce NOW is now supported on Firefox, expanding access across even more devices.
Members can outfox big downloads and jump into high-performance PC gaming directly from the browser — no waiting on lengthy game installs or updates. The experience delivers GeForce RTX-powered performance at up to 1440p and 120 frames per second for GeForce NOW Ultimate members.
Simply download the latest version of Firefox, head to play.geforcenow.com and start playing. The cloud handles the heavy lifting, so games are ready to play without taking up valuable storage space on the device. Firefox joins Chrome, Edge and Opera in supporting GeForce NOW on Windows browsers.
Deploy the Games
Land on the beaches of the Gallipoli Peninsula in BlackMill Games’ Gallipoli, the latest entry in the WW1 Game Series. Fight as soldiers of the British and Ottoman Empires in intense 25v25 objective-based battles across coastal shores, deserts and urban battlefields, with 10 historical classes and over 50 authentic weapons and equipment options.
Teamwork is key in its grounded, one-shot-one-kill combat. Take command as an Officer, provide cover as a Heavy Machine Gunner or Sniper, keep the squad going as a Stretcher Bearer and more while navigating challenging campaigns.
Head to the frontlines from the cloud with no lengthy game downloads or installs taking up local storage space. Play directly in the newly supported Firefox browser, or take the action across PCs, Macs, Chromebooks, handhelds and more with GeForce NOW cloud saves.
In addition, members can look for the following games streaming throughout the week:
Dates listed above reflect when games are released on their respective stores. GeForce NOW availability may vary, as games are onboarded after release and added throughout the week. Keep an eye on GeForce NOW channels and GFN Thursdays for availability updates on announced titles.
To try GeForce NOW in Firefox, start with a GeForce NOW day pass and experience premium cloud gaming directly from the browser. If members later upgrade to a Performance or Ultimate membership, the cost of the day pass can be applied toward the first membership purchase.
What are you planning to play this weekend? Let us know on X or in the comments below.
